↑より引用 Dr. Picard’s translational research program investigates mechanisms of mitochondrial psychobiology. Investigators and trainees in the Mitochondrial Signaling Lab team combine genetic, cellular, imaging, and psychophysiology approaches to examine how psychosocial exposures impact mitochondrial structure and functions, and how energetic perturbations within mitochondria influence key brain-body processes involved in cognition, psychological stress reactivity, and resilience. Their work leverages computational and network approaches based on machine learning to capture molecular patterns of mitochondrial dysregulation across tissues, from organelle to organism.
↑より引用 “Based on our mathematical modeling, we think hair needs to reach a threshold before it turns gray,” Picard says. “In middle age, when the hair is near that threshold because of biological age and other factors, stress will push it over the threshold and it transitions to gray.
“But we don’t think that reducing stress in a 70-year-old who’s been gray for years will darken their hair or increasing stress in a 10-year-old will be enough to tip their hair over the gray threshold.”
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